Serine Biosynthesis Pathway Supports MYC–miR-494–EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells

Serine Biosynthesis Pathway Supports MYC–miR-494–EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells

Burkitt lymphoma (BL) is a rapidly growing tumor, characterized by high anabolic requirements. The <i>MYC</i> oncogene plays a central role in the pathogenesis of this malignancy, controlling genes involved in apoptosis, proliferation, and cellular metabolism. Serine biosynthesis pathway...

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Bibliographic Details
Main Authors: Emilia Białopiotrowicz, Monika Noyszewska-Kania, Neli Kachamakova-Trojanowska, Agnieszka Łoboda, Magdalena Cybulska, Aleksandra Grochowska, Michał Kopczyński, Michał Mikula, Monika Prochorec-Sobieszek, Małgorzata Firczuk, Agnieszka Graczyk-Jarzynka, Radosław Zagożdżon, Adam Ząbek, Piotr Młynarz, Józef Dulak, Patryk Górniak, Maciej Szydłowski, Karolina Pyziak, Justyna Martyka, Agnieszka Sroka-Porada, Ewa Jabłońska, Anna Polak, Piotr Kowalczyk, Anna Szumera-Ciećkiewicz, Bjoern Chapuy, Tomasz Rzymski, Krzysztof Brzózka, Przemysław Juszczyński
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
burkitt lymphoma
myc
serine biosynthesis pathway
metabolism
Online Access:https://www.mdpi.com/2072-6694/12/3/580

Internet

https://www.mdpi.com/2072-6694/12/3/580

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