A multi-component prime-boost vaccination regimen with a consensus MOMP antigen enhances Chlamydia trachomatis clearance.

A multi-component prime-boost vaccination regimen with a consensus MOMP antigen enhances Chlamydia trachomatis clearance.

Background: A vaccine for Chlamydia trachomatis is of urgent medical need. We explored bioinformatic approaches to generate an immunogen against C. trachomatis that would induce cross-serovar T cell responses as (i) CD4+ T cells have been shown in animal models and human studies to be important in c...

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Bibliographic Details
Main Authors: Alexander eBadamchi-Zadeh, Paul F. McKay, Bette T. Korber, Guillermo eBarinaga, Adam A. Walters, Alexandra eNunes, João Paulo Gomes, Frank eFollmann, John S. Tregoning, Robin J. Shattock
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Immunology
Subjects:
Chlamydia trachomatis
prime-boost regimens
Adenovirus-vector vaccines
MVA-vector vaccines
DNA vaccines.
consensus vs mosaic
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00162/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00162/full

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