A multi-component prime-boost vaccination regimen with a consensus MOMP antigen enhances Chlamydia trachomatis clearance.
Background: A vaccine for Chlamydia trachomatis is of urgent medical need. We explored bioinformatic approaches to generate an immunogen against C. trachomatis that would induce cross-serovar T cell responses as (i) CD4+ T cells have been shown in animal models and human studies to be important in c...
Main Authors: | Alexander eBadamchi-Zadeh, Paul F. McKay, Bette T. Korber, Guillermo eBarinaga, Adam A. Walters, Alexandra eNunes, João Paulo Gomes, Frank eFollmann, John S. Tregoning, Robin J. Shattock |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2016-04-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00162/full |
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