Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis

Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis

The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread.

Bibliographic Details
Main Authors: Tamara Muliaditan, Jonathan Caron, Mary Okesola, James W. Opzoomer, Paris Kosti, Mirella Georgouli, Peter Gordon, Sharanpreet Lall, Desislava M. Kuzeva, Luisa Pedro, Jacqueline D. Shields, Cheryl E. Gillett, Sandra S. Diebold, Victoria Sanz-Moreno, Tony Ng, Esther Hoste, James N. Arnold
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05346-7

Internet

https://doi.org/10.1038/s41467-018-05346-7

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