High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers.

It is possible to infer the past of populations by comparing genomes between individuals. In general, older populations have more genomic diversity than younger populations. The force of selection can also be inferred from population diversity. If selection is strong and frequently eliminates less f...

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Bibliographic Details
Main Authors: Kimberly D Siegmund, Paul Marjoram, Simon Tavaré, Darryl Shibata
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3125304?pdf=render