Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design

Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design

Abstract Enterotoxigenic Escherichia coli (ETEC) is estimated to cause approximately 380,000 deaths annually during sporadic or epidemic outbreaks worldwide. Development of vaccines against ETEC is very challenging due to the vast heterogeneity of the ETEC strains. An effective vaccines would have t...

Full description

Bibliographic Details
Main Authors: Alla Amcheslavsky, Aaron L. Wallace, Monir Ejemel, Qi Li, Conor T. McMahon, Matteo Stoppato, Serena Giuntini, Zachary A. Schiller, Jessica R. Pondish, Jacqueline R. Toomey, Ryan M. Schneider, Jordan Meisinger, Raimond Heukers, Andrew C. Kruse, Eileen M. Barry, Brian G. Pierce, Mark S. Klempner, Lisa A. Cavacini, Yang Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81895-0

Internet

https://doi.org/10.1038/s41598-021-81895-0

Similar Items