Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

Abstract A fundamental property of infectious agents is their particulate nature: infectivity arises from independently-acting particles rather than as a result of collective action. Assemblies of the protein tau can exhibit seeding behaviour, potentially underlying the apparent spread of tau aggreg...

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Bibliographic Details
Main Authors: Lauren V. C. Miller, Aamir S. Mukadam, Claire S. Durrant, Marina J. Vaysburd, Taxiarchis Katsinelos, Benjamin J. Tuck, Sophie Sanford, Olivia Sheppard, Claire Knox, Shi Cheng, Leo C. James, Michael P. Coleman, William A. McEwan
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Acta Neuropathologica Communications
Subjects:
Prion-like activity
Tau seeded aggregation
Organotypic hippocampal slice cultures
Neurodegeneration
Tauopathies
Online Access:https://doi.org/10.1186/s40478-021-01141-6

Internet

https://doi.org/10.1186/s40478-021-01141-6

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