Antineoplastic effects of auranofin in human pancreatic adenocarcinoma preclinical models

Background: Auranofin, a Food and Drug Administration–approved anti-rheumatic agent with anticancer properties for lung and ovarian cancer, has never been studied for pancreatic cancer. We hypothesize that auranofin may prevent pancreatic ductal adenocarcinoma progression by inhibition of Txnrd1 and...

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Bibliographic Details
Main Authors: Mayrim V. Rios Perez, David Roife, Bingbing Dai, Michael Pratt, Ryszard Dobrowolski, Ya'an Kang, Xinqun Li, Jithesh J. Augustine, Rafal Zielinski, Waldemar Priebe, Jason B. Fleming
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Surgery Open Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2589845019300119