Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator

Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator

Summary: Ivacaftor (VX-770) was the first cystic fibrosis transmembrane conductance regulator (CFTR) modulatory drug approved for the treatment of patients with cystic fibrosis. Electron cryomicroscopy (cryo-EM) studies of detergent-solubilized CFTR indicated that VX-770 bound to a site at the inter...

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Bibliographic Details
Main Authors: Onofrio Laselva, Zafar Qureshi, Zhi-Wei Zeng, Evgeniy V. Petrotchenko, Mohabir Ramjeesingh, C. Michael Hamilton, Ling-Jun Huan, Christoph H. Borchers, Régis Pomès, Robert Young, Christine E. Bear
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Biochemistry
Biological sciences
Biophysics
Medicine
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221005101

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http://www.sciencedirect.com/science/article/pii/S2589004221005101

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