PERK Pathway Activation Promotes Intracerebral Hemorrhage Induced Secondary Brain Injury by Inducing Neuronal Apoptosis Both in Vivo and in Vitro

PERK Pathway Activation Promotes Intracerebral Hemorrhage Induced Secondary Brain Injury by Inducing Neuronal Apoptosis Both in Vivo and in Vitro

The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) signaling pathway was reported to exert an important role in neuronal apoptosis. The present study was designed to investigate the roles of the PERK signaling pathway in the secondary brain injury (SBI) induced by intracerebral hemo...

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Bibliographic Details
Main Authors: Chengjie Meng, Juyi Zhang, Baoqi Dang, Haiying Li, Haitao Shen, Xiang Li, Zhong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Neuroscience
Subjects:
PERK pathway
intracerebral hemorrhage
secondary brain injury
apoptosis
ER stress
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00111/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00111/full

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