CMTM3 suppresses chordoma progress through EGFR/STAT3 regulated EMT and TP53 signaling pathway

CMTM3 suppresses chordoma progress through EGFR/STAT3 regulated EMT and TP53 signaling pathway

Abstract Background Chordomas are rare, slow-growing and locally aggressive bone sarcomas. At present, chordomas are difficult to manage due to their high recurrence rate, metastasis tendency and poor prognosis. The underlying mechanisms of chordoma tumorigenesis and progression urgently need to be...

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Bibliographic Details
Main Authors: Wanqiong Yuan, Feng Wei, Hanqiang Ouyang, Xiaoqing Ren, Jing Hang, Xiaoning Mo, Zhongjun Liu
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Cancer Cell International
Subjects:
Chordoma
CMTM3
EGFR
STAT3
TP53
Online Access:https://doi.org/10.1186/s12935-021-02159-5

Internet

https://doi.org/10.1186/s12935-021-02159-5

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