Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies

Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies

The ABCB1 transporter also known as P-glycoprotein (P-gp) is a transmembrane protein belonging to the ATP binding cassette super-family of transporters; it is a xenobiotic efflux pump that limits intracellular drug accumulation by pumping the compounds out of cells. P-gp contributes to a decrease of...

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Bibliographic Details
Main Authors: Liadys Mora Lagares, Nikola Minovski, Ana Yisel Caballero Alfonso, Emilio Benfenati, Sara Wellens, Maxime Culot, Fabien Gosselet, Marjana Novič
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
P-glycoprotein
molecular docking
protein homology modeling
caco-2 pump out assay
Online Access:https://www.mdpi.com/1422-0067/21/11/4058

Internet

https://www.mdpi.com/1422-0067/21/11/4058

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