Suppression of Tumor Recurrence and Metastasis by a Combination of the PHSCN Sequence and the Antiangiogenic Compound Tetrathiomolybdate in Prostate Carcinoma

Suppression of Tumor Recurrence and Metastasis by a Combination of the PHSCN Sequence and the Antiangiogenic Compound Tetrathiomolybdate in Prostate Carcinoma

Plasma fibronectin-mediated invasion of human DU145 prostate cancer cell line was efficaciously inhibited in a rat tumor model by treatment with Ac-PHSCN-NH2 peptide. Invasion of DU145 cells was stimulated by the PHSCN sequence of plasma fibronectin. However, PHSCN acts as a competitive inhibitor o...

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Bibliographic Details
Main Authors: Kenneth L. van Golen, LiWei Bao, George J. Brewert, Kenneth J. Pienta, Jeffrey M. Kamradt, Donna L. Livant, Sofia D. Merajver
Format: Article
Language:English
Published: Elsevier 2002-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
prostate carcinoma
PHSCN
tetrathiomolybdate
metastasis
tumor recurrence
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860280032X

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http://www.sciencedirect.com/science/article/pii/S147655860280032X

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