SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells

SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells

Abstract Cystic fibrosis (CF) occurs as a result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which lead to misfolding, trafficking defects, and impaired function of the CFTR protein. Splicing factor proline/glutamine-rich (SFPQ) is a multifunctional nuclear R...

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Bibliographic Details
Main Authors: Parameet Kumar, Dharmendra Kumar Soni, Chaitali Sen, Mads B. Larsen, Krystyna Mazan-Mamczarz, Yulan Piao, Supriyo De, Myriam Gorospe, Raymond A. Frizzell, Roopa Biswas
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96141-w

Internet

https://doi.org/10.1038/s41598-021-96141-w

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