Congenital heart block maternal sera autoantibodies target an extracellular epitope on the α1G T-type calcium channel in human fetal hearts.

Congenital heart block maternal sera autoantibodies target an extracellular epitope on the α1G T-type calcium channel in human fetal hearts.

Congenital heart block (CHB) is a transplacentally acquired autoimmune disease associated with anti-Ro/SSA and anti-La/SSB maternal autoantibodies and is characterized primarily by atrioventricular (AV) block of the fetal heart. This study aims to investigate whether the T-type calcium channel subun...

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Bibliographic Details
Main Authors: Linn S Strandberg, Xuezhi Cui, Arianna Rath, Jie Liu, Earl D Silverman, Xiaoru Liu, Vinayakumar Siragam, Cameron Ackerley, Brenda Bin Su, Jane Yuqing Yan, Marco Capecchi, Luca Biavati, Alice Accorroni, William Yuen, Filippo Quattrone, Kalvin Lung, Edgar T Jaeggi, Peter H Backx, Charles M Deber, Robert M Hamilton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3767782?pdf=render

Internet

http://europepmc.org/articles/PMC3767782?pdf=render

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