Impairment of mitochondrial unfolded protein response contribute to resistance declination of H2O2‐induced injury in senescent MRC‐5 cell model

Impairment of mitochondrial unfolded protein response contribute to resistance declination of H2O2‐induced injury in senescent MRC‐5 cell model

Abstract Accumulation of oxidative proteins within mitochondria leads to loss of mitochondrial function, which may lead to age‐related degenerative diseases. Mitochondrial antioxidant defense capacity reflects the expression of mitochondrial unfolded protein response (mtUPR)‐related proteins. Senesc...

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Bibliographic Details
Main Authors: Tzu‐Ying Lee, Li‐Ju Huang, Huei‐Ping Dong, Yoshioka Tohru, Bo‐Hong Liu, Rei‐Cheng Yang
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
mitochondrial unfolded protein response
oxidative stress
senescent fibroblasts
STIM1‐Orai1‐dependent SOCE
Online Access:https://doi.org/10.1002/kjm2.12146

Internet

https://doi.org/10.1002/kjm2.12146

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