Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature
Saliva is a biofluid that can be considered as a “mirror” reflecting our body’s health status. Vibrational spectroscopy, Raman and infrared, can provide a detailed salivary fingerprint that can be used for disease biomarker discovery. We propose a systematic literature review based on the PRISMA (Pr...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-09-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/18/4142 |
id |
doaj-8c88357493254316b69b235eda333f08 |
---|---|
record_format |
Article |
spelling |
doaj-8c88357493254316b69b235eda333f082020-11-25T03:27:48ZengMDPI AGMolecules1420-30492020-09-01254142414210.3390/molecules25184142Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic LiteratureStéphane Derruau0Julien Robinet1Valérie Untereiner2Olivier Piot3Ganesh D. Sockalingum4Sandrine Lorimier5Département de Biologie Orale, UFR Odontologie, Université de Reims Champagne-Ardenne, 2 rue du Général Koenig, 51100 Reims, FranceDépartement de Biologie Orale, UFR Odontologie, Université de Reims Champagne-Ardenne, 2 rue du Général Koenig, 51100 Reims, FrancePICT, Université de Reims Champagne-Ardenne, 51 rue Cognacq-Jay, 51097 Reims, FranceBioSpecT-EA7506, UFR de Pharmacie, Université de Reims Champagne-Ardenne, 51 rue Cognacq-Jay, 51097 Reims, FranceBioSpecT-EA7506, UFR de Pharmacie, Université de Reims Champagne-Ardenne, 51 rue Cognacq-Jay, 51097 Reims, FranceDépartement de Biologie Orale, UFR Odontologie, Université de Reims Champagne-Ardenne, 2 rue du Général Koenig, 51100 Reims, FranceSaliva is a biofluid that can be considered as a “mirror” reflecting our body’s health status. Vibrational spectroscopy, Raman and infrared, can provide a detailed salivary fingerprint that can be used for disease biomarker discovery. We propose a systematic literature review based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines to evaluate the potential of vibrational spectroscopy to diagnose oral and general diseases using saliva as a biological specimen. Literature searches were recently conducted in May 2020 through MEDLINE-PubMed and Scopus databases, without date limitation. Finally, over a period of 10 years, 18 publications were included reporting on 10 diseases (three oral and seven general diseases), with very high diagnostic performance rates in terms of sensitivity, specificity, and accuracy. Thirteen articles were related to six different cancers of the following anatomical sites: mouth, nasopharynx, lung, esophagus, stomach, and breast. The other diseases investigated and included in this review were periodontitis, Sjögren’s syndrome, diabetes, and myocardial infarction. Moreover, most articles focused on Raman spectroscopy (<i>n </i>= 16/18) and more specifically surface-enhanced Raman spectroscopy (<i>n </i>= 12/18). Interestingly, vibrational spectroscopy appears promising as a rapid, label-free, and non-invasive diagnostic salivary biometric tool. Furthermore, it could be adapted to investigate subclinical diseases—even if developmental studies are required.https://www.mdpi.com/1420-3049/25/18/4142salivavibrational spectroscopyRamaninfrareddiagnosissystematic review |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stéphane Derruau Julien Robinet Valérie Untereiner Olivier Piot Ganesh D. Sockalingum Sandrine Lorimier |
spellingShingle |
Stéphane Derruau Julien Robinet Valérie Untereiner Olivier Piot Ganesh D. Sockalingum Sandrine Lorimier Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature Molecules saliva vibrational spectroscopy Raman infrared diagnosis systematic review |
author_facet |
Stéphane Derruau Julien Robinet Valérie Untereiner Olivier Piot Ganesh D. Sockalingum Sandrine Lorimier |
author_sort |
Stéphane Derruau |
title |
Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature |
title_short |
Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature |
title_full |
Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature |
title_fullStr |
Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature |
title_full_unstemmed |
Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature |
title_sort |
vibrational spectroscopy saliva profiling as biometric tool for disease diagnostics: a systematic literature |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-09-01 |
description |
Saliva is a biofluid that can be considered as a “mirror” reflecting our body’s health status. Vibrational spectroscopy, Raman and infrared, can provide a detailed salivary fingerprint that can be used for disease biomarker discovery. We propose a systematic literature review based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines to evaluate the potential of vibrational spectroscopy to diagnose oral and general diseases using saliva as a biological specimen. Literature searches were recently conducted in May 2020 through MEDLINE-PubMed and Scopus databases, without date limitation. Finally, over a period of 10 years, 18 publications were included reporting on 10 diseases (three oral and seven general diseases), with very high diagnostic performance rates in terms of sensitivity, specificity, and accuracy. Thirteen articles were related to six different cancers of the following anatomical sites: mouth, nasopharynx, lung, esophagus, stomach, and breast. The other diseases investigated and included in this review were periodontitis, Sjögren’s syndrome, diabetes, and myocardial infarction. Moreover, most articles focused on Raman spectroscopy (<i>n </i>= 16/18) and more specifically surface-enhanced Raman spectroscopy (<i>n </i>= 12/18). Interestingly, vibrational spectroscopy appears promising as a rapid, label-free, and non-invasive diagnostic salivary biometric tool. Furthermore, it could be adapted to investigate subclinical diseases—even if developmental studies are required. |
topic |
saliva vibrational spectroscopy Raman infrared diagnosis systematic review |
url |
https://www.mdpi.com/1420-3049/25/18/4142 |
work_keys_str_mv |
AT stephanederruau vibrationalspectroscopysalivaprofilingasbiometrictoolfordiseasediagnosticsasystematicliterature AT julienrobinet vibrationalspectroscopysalivaprofilingasbiometrictoolfordiseasediagnosticsasystematicliterature AT valerieuntereiner vibrationalspectroscopysalivaprofilingasbiometrictoolfordiseasediagnosticsasystematicliterature AT olivierpiot vibrationalspectroscopysalivaprofilingasbiometrictoolfordiseasediagnosticsasystematicliterature AT ganeshdsockalingum vibrationalspectroscopysalivaprofilingasbiometrictoolfordiseasediagnosticsasystematicliterature AT sandrinelorimier vibrationalspectroscopysalivaprofilingasbiometrictoolfordiseasediagnosticsasystematicliterature |
_version_ |
1724587009177026560 |