Blood–brain barrier abnormalities caused by exposure to HIV-1 gp120 — Protection by gene delivery of antioxidant enzymes

Blood–brain barrier abnormalities caused by exposure to HIV-1 gp120 — Protection by gene delivery of antioxidant enzymes

HIV-1 effects on the blood–brain barrier (BBB) structure and function are still poorly understood in animal models based on direct administration of recombinant HIV proteins. We therefore injected HIV-1 envelope glycoprotein, gp120, into rat caudate-putamens (CPs) and examined vascular integrity and...

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Bibliographic Details
Main Authors: Jean-Pierre Louboutin, Beverly A.S. Reyes, Lokesh Agrawal, Christina R. Maxwell, Elisabeth J. Van Bockstaele, David S. Strayer
Format: Article
Language:English
Published: Elsevier 2010-05-01
Series:Neurobiology of Disease
Subjects:
Blood–brain barrier
Endothelial cells
Gp120
HIV-1
Oxidative stress
Gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000549

Internet

http://www.sciencedirect.com/science/article/pii/S0969996110000549

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