THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency

THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency

The role played by microglia has taken the center of the stage in the etiology of Alzheimer's disease (AD). Several genome-wide association studies carried out on large cohorts of patients have indeed revealed a large number of genetic susceptibility factors corresponding to genes involved in n...

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Bibliographic Details
Main Authors: Audrey Vautheny, Charlotte Duwat, Gwennaëlle Aurégan, Charlène Joséphine, Anne-Sophie Hérard, Caroline Jan, Julien Mitja, Pauline Gipchtein, Marie-Claude Gaillard, Luc Buée, David Blum, Philippe Hantraye, Gilles Bonvento, Emmanuel Brouillet, Karine Cambon, Alexis-Pierre Bemelmans
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
Tauopathy
Microglia
Trem2
Animal model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001479

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http://www.sciencedirect.com/science/article/pii/S0969996121001479

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