BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62

BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62

Molecular chaperones are critical to maintaining intracellular proteostasis and have been shown to have a protective role against alpha-synuclein-mediated toxicity. Co-chaperone proteins regulate the activity of molecular chaperones and connect the chaperone network to protein degradation and cell d...

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Bibliographic Details
Main Authors: Erik L. Friesen, Yu Tong Zhang, Rebecca Earnshaw, Mitch L. De Snoo, Darren M. O’Hara, Victoria Agapova, Hien Chau, Sophie Ngana, Kevin S. Chen, Lorraine V. Kalia, Suneil K. Kalia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
alpha-synuclein
chaperones
bcl-2 associated athanogene
BAG5
proteostasis
p62
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00716/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00716/full

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