Effects of Claudin-1 on the Action of <i>Clostridium perfringens</i> Enterotoxin in Caco-2 Cells

<i>Clostridium perfringens</i> enterotoxin (CPE) contributes to diarrhea and an often-lethal enterotoxemia. CPE action starts when it binds to claudin receptors, forming a small complex (90 kDa). Six small complexes then oligomerize to create prepores, followed by insertion of beta-hairp...

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Bibliographic Details
Main Authors: Iman Mehdizadeh Gohari, Jihong Li, Mauricio Navarro, Francisco Uzal, Bruce McClane
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Toxins
Subjects:
Online Access:https://www.mdpi.com/2072-6651/11/10/582