Corneal keratin aggresome (CKAGG) formation and clearance by proteasome activation

Purpose: To understand the mechanism of corneal keratin expression and clearance in corneal epithelium with Limbal Stem Cell Deficiency (LSCD). The hypothesis is that LSCD-induced proteasome dysfunction is a contributing factor to keratin aggregation, causing corneal keratin aggresome (CKAGG) format...

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Bibliographic Details
Main Authors: Fawzia Bardag-Gorce, Andrew Makalinao, Imara Meepe, Richard H. Hoft, Daileen Cortez, Joan Oliva, Amanda Laporte, Jeremy Stark, Amber Gorce, Michael Di Lorenzo, Samuel W. French, William Lungo, Yutaka Niihara
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018361450