IRF8 Impacts Self‐Renewal of Hematopoietic Stem Cells by Regulating TLR9 Signaling Pathway of Innate Immune Cells

IRF8 Impacts Self‐Renewal of Hematopoietic Stem Cells by Regulating TLR9 Signaling Pathway of Innate Immune Cells

Abstract IRF8 is a key regulator of innate immunity receptor signaling and plays diverse functions in the development of hematopoietic cells. The effects of IRF8 on hematopoietic stem cells (HSCs) are still unknown. Here, it is demonstrated that IRF8 deficiency results in a decreased number of long‐...

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Bibliographic Details
Main Authors: Donghe Li, Yuyin Zhang, Qingsong Qiu, Jinzeng Wang, Xuemei Zhao, Bo Jiao, Xiuli Zhang, Shanhe Yu, Pengfei Xu, Yuqing Dan, Xinhua Xiao, Peihong Wang, Mingzhu Liu, Zhizhou Xia, Zhangsen Huang, Ruihong Zhang, Jiaoyang Li, Xi Xie, Yan Zhang, Chenxuan Liu, Ping Liu, Ruibao Ren
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Advanced Science
Subjects:
hematopoietic stem cells
IRF8
natural killer cells
proinflammatory cytokines
TLR9
Online Access:https://doi.org/10.1002/advs.202101031

Internet

https://doi.org/10.1002/advs.202101031

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