Evaluation of the Pharmacokinetics of Intranasal Drug Delivery for Targeting Cervical Lymph Nodes in Rats

Evaluation of the Pharmacokinetics of Intranasal Drug Delivery for Targeting Cervical Lymph Nodes in Rats

A well-developed lymphatic network is located under the nasal mucosa, and a few drugs that permeate the nasal mucosa are absorbed into the lymphatic capillaries. Lymph from the nasal cavity flows to the cervical lymph nodes (CLNs). In this study, we evaluated the pharmacokinetics of the direct trans...

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Bibliographic Details
Main Authors: Tomoyuki Furubayashi, Daisuke Inoue, Shunsuke Kimura, Akiko Tanaka, Toshiyasu Sakane
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
intranasal
cervical lymph nodes
pharmacokinetic
methotrexate
targeted drug delivery
Online Access:https://www.mdpi.com/1999-4923/13/9/1363

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https://www.mdpi.com/1999-4923/13/9/1363

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