Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric <i>MLL</i>-Rearranged Acute Lymphoblastic Leukemia

Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric <i>MLL</i>-Rearranged Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) in infants (<1 year of age) remains one of the most aggressive types of childhood hematologic malignancy. The majority (~80%) of infant ALL cases are characterized by chromosomal translocations involving the <i>MLL</i> (or <i>KMT2A</i>) g...

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Bibliographic Details
Main Authors: Mark Kerstjens, Patricia Garrido Castro, Sandra S. Pinhanços, Pauline Schneider, Priscilla Wander, Rob Pieters, Ronald W. Stam
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
<i>MLL</i> translocation
pediatric acute leukemia
irinotecan
xenograft mouse models
Online Access:https://www.mdpi.com/2227-9059/9/7/711

Internet

https://www.mdpi.com/2227-9059/9/7/711

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