The effect of Apremilast on signal transduction and IL-10 production in CD39high regulatory B cells in patients with psoriatic arthritis

The effect of Apremilast on signal transduction and IL-10 production in CD39high regulatory B cells in patients with psoriatic arthritis

Background. IL-10-producing regulatory B cells (Bregs) are of great importance in autoimmunity, as they inhibit proinflammatory T cells. We have shown that IL-10-producing Bregs in psoriatic arthritis(PsA) were decreased and inversely correlated with IFNγ+T cells (TH1 cells) and IL-17+ T cells (TH17...

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Bibliographic Details
Main Authors: Lazaros I. Sakkas, Athanasios Mavropoulos, Efterpi Zafiriou, Aggeliki Roussaki-Schulze, Dimitrios P. Bogdanos
Format: Article
Language:English
Published: PCO Convin S.A. 2018-01-01
Series:Mediterranean Journal of Rheumatology
Subjects:
apremilast
cd39
psoriatic arthritis
psoriasis
regulatory b cells
t cells
Online Access:https://www.mjrheum.org/assets/files/792/file121_879.pdf

Internet

https://www.mjrheum.org/assets/files/792/file121_879.pdf

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