The effect of Apremilast on signal transduction and IL-10 production in CD39high regulatory B cells in patients with psoriatic arthritis
Background. IL-10-producing regulatory B cells (Bregs) are of great importance in autoimmunity, as they inhibit proinflammatory T cells. We have shown that IL-10-producing Bregs in psoriatic arthritis(PsA) were decreased and inversely correlated with IFNγ+T cells (TH1 cells) and IL-17+ T cells (TH17...
Main Authors: | Lazaros I. Sakkas, Athanasios Mavropoulos, Efterpi Zafiriou, Aggeliki Roussaki-Schulze, Dimitrios P. Bogdanos |
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Format: | Article |
Language: | English |
Published: |
PCO Convin S.A.
2018-01-01
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Series: | Mediterranean Journal of Rheumatology |
Subjects: | |
Online Access: | https://www.mjrheum.org/assets/files/792/file121_879.pdf |
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