Monomeric and dimeric CXCL8 are both essential for in vivo neutrophil recruitment.

Rapid mobilization of neutrophils from vasculature to the site of bacterial/viral infections and tissue injury is a critical step in successful resolution of inflammation. The chemokine CXCL8 plays a central role in recruiting neutrophils. A characteristic feature of CXCL8 is its ability to reversib...

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Bibliographic Details
Main Authors: Sandhya Thulasi Das, Lavanya Rajagopalan, Antonieta Guerrero-Plata, Jiqing Sai, Ann Richmond, Roberto P Garofalo, Krishna Rajarathnam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2909905?pdf=render