An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8+ T Cells

An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8+ T Cells

Multiple independent adeno-associated virus (AAV) gene therapy clinical trials for hemophilia B, utilizing different AAV serotypes, have reported a vector dose-dependent loss of circulating factor IX (FIX) protein associated with capsid-specific CD8+ T cell (Cap-CD8) elimination of transduced hepato...

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Bibliographic Details
Main Authors: Brett Palaschak, Damien Marsic, Roland W. Herzog, Sergei Zolotukhin, David M. Markusic
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV vector
capsid immunity
mouse model
hemophilia
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300591

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http://www.sciencedirect.com/science/article/pii/S2329050117300591

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