The Influence of Energy Depletion by Metformin or Hypocaloric Diet on Thyroid Iodine Uptake in Healthy Volunteers: a Randomized Trial

The Influence of Energy Depletion by Metformin or Hypocaloric Diet on Thyroid Iodine Uptake in Healthy Volunteers: a Randomized Trial

Abstract Sufficient thyroid iodine uptake is needed to ensure effective radioactive iodine (RAI) treatment, which is mediated by the sodium-iodide symporter (NIS). Activation of AMP-activated-protein-kinase (AMPK), leads to decreased NIS expression and thyroid iodine uptake in in vitro and animal mo...

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Bibliographic Details
Main Authors: Yvette J. E. Sloot, Marcel J. R. Janssen, Antonius E. van Herwaarden, Robin P. Peeters, Romana T. Netea-Maier, Johannes W. A. Smit
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-41997-2

Internet

https://doi.org/10.1038/s41598-019-41997-2

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