A Translational Mouse Model for NASH with Advanced Fibrosis and Atherosclerosis Expressing Key Pathways of Human Pathology

A Translational Mouse Model for NASH with Advanced Fibrosis and Atherosclerosis Expressing Key Pathways of Human Pathology

Non-alcoholic steatohepatitis (NASH) is a fast-growing liver disorder that is associated with an increased incidence of cardiovascular disease and type 2 diabetes. Animal models adequately mimicking this condition are scarce. We herein investigate whether Ldlr−/−. Leiden mice on different high-fat d...

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Bibliographic Details
Main Authors: Anita M. van den Hoek, Lars Verschuren, Nicole Worms, Anita van Nieuwkoop, Christa de Ruiter, Joline Attema, Aswin L. Menke, Martien P. M. Caspers, Sridhar Radhakrishnan, Kanita Salic, Robert Kleemann
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
NAFLD
NASH
inflammation
fibrosis
metabolic syndrome
atherosclerosis
Online Access:https://www.mdpi.com/2073-4409/9/9/2014

Internet

https://www.mdpi.com/2073-4409/9/9/2014

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