The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury.

The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury.

The extent of damage following spinal cord injury (SCI) can be reduced by various neuroprotective regimens that include maintaining levels of cyclic adenosine monophosphate (cyclic AMP), via administration of the phosphodiesterase 4 (PDE4) inhibitor Rolipram. The current study sought to determine th...

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Bibliographic Details
Main Authors: Sandra Marie Schaal, Maneesh Sen Garg, Mousumi Ghosh, Lilie Lovera, Michael Lopez, Monal Patel, Jack Louro, Samik Patel, Luis Tuesta, Wai-Man Chan, Damien Daniel Pearse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3446989?pdf=render

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http://europepmc.org/articles/PMC3446989?pdf=render

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