Rodent heart failure models do not reflect the human circulating microRNA signature in heart failure.

Rodent heart failure models do not reflect the human circulating microRNA signature in heart failure.

We recently identified a set of plasma microRNAs (miRNAs) that are downregulated in patients with heart failure in comparison with control subjects. To better understand their meaning and function, we sought to validate these circulating miRNAs in 3 different well-established rat and mouse heart fai...

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Bibliographic Details
Main Authors: Eline L Vegter, Ekaterina S Ovchinnikova, Herman H W Silljé, Laura M G Meems, Atze van der Pol, A Rogier van der Velde, Eugene Berezikov, Adriaan A Voors, Rudolf A de Boer, Peter van der Meer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5419653?pdf=render

Internet

http://europepmc.org/articles/PMC5419653?pdf=render

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