Mendelian randomization case-control PheWAS in UK Biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions

Mendelian randomization case-control PheWAS in UK Biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions

Background: Smoking is one of the greatest threats to public health worldwide. We integrated phenome-wide association study (PheWAS) and Mendelian randomization (MR) approaches to explore causal effects of genetically predicted smoking intensity across the human disease spectrum. Methods: We conduct...

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Bibliographic Details
Main Authors: Catherine King, Anwar Mulugeta, Farhana Nabi, Robert Walton, Ang Zhou, Elina Hyppönen
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:EClinicalMedicine
Subjects:
PheWAS
Phenome-wide
MR
mendelian randomisation
Smoking
Intensity
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537020302327

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http://www.sciencedirect.com/science/article/pii/S2589537020302327

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