Progesterone and Allopregnanolone Rapidly Attenuate Estrogen-Associated Mechanical Allodynia in Rats with Persistent Temporomandibular Joint Inflammation

Progesterone and Allopregnanolone Rapidly Attenuate Estrogen-Associated Mechanical Allodynia in Rats with Persistent Temporomandibular Joint Inflammation

Temporomandibular joint disorder (TMD) is associated with pain in the joint (temporomandibular joint, TMJ) and muscles involved in mastication. TMD pain dissipates following menopause but returns in some women undergoing estrogen replacement therapy. Progesterone has both anti-inflammatory and antin...

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Bibliographic Details
Main Authors: Rebecca S. Hornung, William L. Benton, Sirima Tongkhuya, Lynda Uphouse, Phillip R. Kramer, Dayna Loyd Averitt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Integrative Neuroscience
Subjects:
orofacial pain
progesterone
estrogen
mechanical allodynia
temporomandibular joint
inflammatory pain
Online Access:https://www.frontiersin.org/article/10.3389/fnint.2020.00026/full

Internet

https://www.frontiersin.org/article/10.3389/fnint.2020.00026/full

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