Effects of Thrombomodulin in Reducing Lethality and Suppressing Neutrophil Extracellular Trap Formation in the Lungs and Liver in a Lipopolysaccharide-Induced Murine Septic Shock Model

Effects of Thrombomodulin in Reducing Lethality and Suppressing Neutrophil Extracellular Trap Formation in the Lungs and Liver in a Lipopolysaccharide-Induced Murine Septic Shock Model

Neutrophil extracellular trap (NET) formation, an innate immune system response, is associated with thrombogenesis and vascular endothelial injury. Circulatory disorders due to microvascular thrombogenesis are one of the principal causes of organ damage. NET formation in organs contributes to the ex...

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Bibliographic Details
Main Authors: Yu Kato, Osamu Nishida, Naohide Kuriyama, Tomoyuki Nakamura, Takahiro Kawaji, Takanori Onouchi, Daisuke Hasegawa, Yasuyo Shimomura
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
neutrophil extracellular traps (NETs)
sepsis
thrombomodulin
lipopolysaccharide (LPS)
organ dysfunction
Online Access:https://www.mdpi.com/1422-0067/22/9/4933

Internet

https://www.mdpi.com/1422-0067/22/9/4933

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