IL-6 stimulates intestinal epithelial proliferation and repair after injury.

IL-6 is a pleiotropic cytokine often associated with inflammation. Inhibition of this pathway has led to successful treatment of rheumatoid arthritis, but one unforeseen potential complication of anti-IL-6 therapy is bowel perforation. Within the intestine, IL-6 has been shown to prevent epithelial...

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Bibliographic Details
Main Authors: Kristine A Kuhn, Nicholas A Manieri, Ta-Chiang Liu, Thaddeus S Stappenbeck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4257684?pdf=render