Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain

Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain

The role of Sirtuins in brain function is emerging, yet little is known about SIRT5 in this domain. Our previous work demonstrates that protein kinase C epsilon (PKCε)-induced protection from focal ischemia is lost in SIRT5−/− mice. Thus, metabolic regulation by SIRT5 contributes significantly to is...

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Bibliographic Details
Main Authors: Kevin B. Koronowski, Nathalie Khoury, Kahlilia C. Morris-Blanco, Holly M. Stradecki-Cohan, Timothy J. Garrett, Miguel A. Perez-Pinzon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Neuroscience
Subjects:
brain metabolism
cerebral ischemia
ischemic preconditioning
protein kinase C epsilon
SIRT5
sirtuins
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00032/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00032/full

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