Simulation-based benchmarking of isoform quantification in single-cell RNA-seq

Simulation-based benchmarking of isoform quantification in single-cell RNA-seq

Abstract Single-cell RNA-seq has the potential to facilitate isoform quantification as the confounding factor of a mixed population of cells is eliminated. However, best practice for using existing quantification methods has not been established. We carry out a benchmark for five popular isoform qua...

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Bibliographic Details
Main Authors: Jennifer Westoby, Marcela Sjöberg Herrera, Anne C. Ferguson-Smith, Martin Hemberg
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Genome Biology
Subjects:
scRNA-seq
Benchmark
Isoform quantification
Single cell
Bulk RNA-seq
Online Access:http://link.springer.com/article/10.1186/s13059-018-1571-5

Internet

http://link.springer.com/article/10.1186/s13059-018-1571-5

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