Orthogonal dual thiol–chloroacetyl and thiol–ene couplings for the sequential one-pot assembly of heteroglycoclusters

Orthogonal dual thiol–chloroacetyl and thiol–ene couplings for the sequential one-pot assembly of heteroglycoclusters

We describe the first one-pot orthogonal strategy to prepare well-defined cyclopeptide-based heteroglycoclusters (hGCs) from glycosyl thiols. Both thiol–chloroactetyl coupling (TCC) and thiol–ene coupling (TEC) have been used to decorate cyclopeptides regioselectively with diverse combination of sug...

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Bibliographic Details
Main Authors: Michele Fiore, Gour Chand Daskhan, Baptiste Thomas, Olivier Renaudet
Format: Article
Language:English
Published: Beilstein-Institut 2014-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
chemoselective ligation
heteroglycocluster
multivalency
multivalent glycosystems
one-pot synthesis
Online Access:https://doi.org/10.3762/bjoc.10.160

Internet

https://doi.org/10.3762/bjoc.10.160

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