Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate

Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate

One of the possible causes of enhanced atherosclerosis in patients with chronic kidney disease (CKD) is the accumulation of uremic toxins. Since macrophage foam cell formation is a hallmark of atherosclerosis, we examined the direct effect of indoxyl sulfate (IS), a representative uremic toxin, on m...

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Bibliographic Details
Main Authors: Koji Matsuo, Suguru Yamamoto, Takuya Wakamatsu, Yoshimitsu Takahashi, Kazuko Kawamura, Yoshikatsu Kaneko, Shin Goto, Junichiro J. Kazama, Ichiei Narita
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Toxins
Subjects:
indoxyl sulfate
macrophage
chronic kidney disease
atherosclerosis
Online Access:http://www.mdpi.com/2072-6651/7/8/3155

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http://www.mdpi.com/2072-6651/7/8/3155

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