Inactivation of CDK/pRb pathway normalizes survival pattern of lymphoblasts expressing the FTLD-progranulin mutation c.709-1G>A.

Inactivation of CDK/pRb pathway normalizes survival pattern of lymphoblasts expressing the FTLD-progranulin mutation c.709-1G>A.

<h4>Background</h4>Mutations in the progranulin (PGRN) gene, leading to haploinsufficiency, cause familial frontotemporal lobar degeneration (FTLD-TDP), although the pathogenic mechanism of PGRN deficit is largely unknown. Allelic loss of PGRN was previously shown to increase the activit...

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Bibliographic Details
Main Authors: Carolina Alquezar, Noemí Esteras, Ainhoa Alzualde, Fermín Moreno, Matilde S Ayuso, Adolfo López de Munain, Ángeles Martín-Requero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22623979/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22623979/?tool=EBI

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