Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway

Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway

Abstract Background Glioblastoma (GBM) is an extremely deadly form of brain cancer with limited treatment options and thus novel therapeutic modalities are necessary. Histone deacetylase inhibitors (HDACi) have demonstrated clinical and preclinical activities against GBM. (Silent mating type informa...

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Bibliographic Details
Main Authors: Tian Ye, Liwen Wei, Ji Shi, Ke Jiang, Huizhe Xu, Lulu Hu, Lingkai Kong, Ye Zhang, Songshu Meng, Haozhe Piao
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cancer
Subjects:
Sirt1
Endoplasmic reticulum stress
Glioma
STAT3
NF-κB
Online Access:http://link.springer.com/article/10.1186/s12885-019-5852-5

Internet

http://link.springer.com/article/10.1186/s12885-019-5852-5

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