Circadian Rhythm Protein Bmal1 Modulates Cartilage Gene Expression in Temporomandibular Joint Osteoarthritis via the MAPK/ERK Pathway

Circadian Rhythm Protein Bmal1 Modulates Cartilage Gene Expression in Temporomandibular Joint Osteoarthritis via the MAPK/ERK Pathway

The purpose of this study was to elucidate the role of the circadian gene Bmal1 in human cartilage and its crosstalk with the MAPK/ERK signaling pathway in temporomandibular joint osteoarthritis (TMJ-OA). We verified the periodical variation of the circadian gene Bmal1 and then established a modifie...

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Bibliographic Details
Main Authors: Guokun Chen, Haoming Zhao, Shixing Ma, Lei Chen, Gaoyi Wu, Yong Zhu, Jie Zhu, Chuan Ma, Huaqiang Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
circadian rhythm disturbance
osteoarthritis
temporomandibular joint
BMAL-1
cartilage
interleukin-6
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.527744/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.527744/full

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