Aberrant MCM10 SUMOylation induces genomic instability mediated by a genetic variant associated with survival of esophageal squamous cell carcinoma

Aberrant MCM10 SUMOylation induces genomic instability mediated by a genetic variant associated with survival of esophageal squamous cell carcinoma

Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the common gastrointestinal malignancy with an inferior prognosis outcome. DNA replication licensing aberration induced by dysregulation of minichromosome maintenance proteins (MCMs) causes genomic instability and cancer metasta...

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Bibliographic Details
Main Authors: Jianbo Tian, Zequn Lu, Siyuan Niu, Shanshan Zhang, Pingting Ying, Lu Wang, Ming Zhang, Yimin Cai, Tianyi Dong, Ying Zhu, Rong Zhong, Zhihua Wang, Jiang Chang, Xiaoping Miao
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Clinical and Translational Medicine
Subjects:
ESCC
genomic instability
MCM10
SUMOylation
survival
Online Access:https://doi.org/10.1002/ctm2.485

Internet

https://doi.org/10.1002/ctm2.485

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