Pathogenic role of the CRL4 ubiquitin ligase in human disease
The cullin 4-RING ubiquitin ligase (CRL4) family employs multiple DCAF (DDB1-CUL4 associated factors) substrate receptors to direct the degradation of proteins involved in a wide spectrum of cellular functions. Aberrant expression of the cullin 4A (CUL4A) gene is found in many tumor types, while mut...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00021/full |