Somatic Deletion in Exon 10 of Aryl Hydrocarbon Receptor Gene in Human GH-Secreting Pituitary Tumors

Somatic Deletion in Exon 10 of Aryl Hydrocarbon Receptor Gene in Human GH-Secreting Pituitary Tumors

Objective/PurposeThe aryl hydrocarbon receptor (AHR) pathway plays a critical role in the biology of Growth Hormone (GH)-secreting pituitary tumor (somatotropinoma). Germline rs2066853 AHR variant was found to be more frequent among acromegaly patients and associated with a more severe disease with...

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Bibliographic Details
Main Authors: Agnese Re, Francesco Ferraù, Concetta Cafiero, Federica Spagnolo, Valeria Barresi, Daniela Petronilla Romeo, Marta Ragonese, Claudio Grassi, Alfredo Pontecorvi, Antonella Farsetti, Salvatore Cannavò
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Endocrinology
Subjects:
pituitary adenoma
acromegaly
aryl hydrocarbon receptor
somatic deletion
sequencing analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.591039/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.591039/full

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