Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification

Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification

Aortic valvular interstitial cells (VICs) isolated from patients undergoing valve replacement are commonly used as in vitro models of calcific aortic valve disease (CAVD). Standardization of VIC calcification, however, has not been implemented, which impairs comparison of results from different stud...

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Bibliographic Details
Main Authors: Shinji Goto, Maximillian A. Rogers, Mark C. Blaser, Hideyuki Higashi, Lang H. Lee, Florian Schlotter, Simon C. Body, Masanori Aikawa, Sasha A. Singh, Elena Aikawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
calcific aortic valve disease
valvular interstitial cells
cardiovascular calcification
ALPL/TNAP
osteogenic differentiation
proteomics
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2019.00049/full

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https://www.frontiersin.org/article/10.3389/fcvm.2019.00049/full

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