Modulation of vascular contraction via soluble guanylate cyclase signaling in a novel ex vivo method using rat precision‐cut liver slices

Modulation of vascular contraction via soluble guanylate cyclase signaling in a novel ex vivo method using rat precision‐cut liver slices

Abstract Fibrotic processes in the liver of non‐alcoholic steatohepatitis (NASH) patients cause microcirculatory dysfunction in the organ which increases blood vessel resistance and causes portal hypertension. Assessing blood vessel function in the liver is challenging, necessitating the development...

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Bibliographic Details
Main Authors: Anouk Oldenburger, Gerald Birk, Marco Schlepütz, Andre Broermann, Birgit Stierstorfer, Steven S. Pullen, Jörg F. Rippmann
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Pharmacology Research & Perspectives
Subjects:
blood vessel contraction
cGMP
ex vivo model
NASH
portal hypertension
translation
Online Access:https://doi.org/10.1002/prp2.768

Internet

https://doi.org/10.1002/prp2.768

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