Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors

Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors

Abstract Background A high rate of glycolysis leading to elevated lactate content has been linked to poor clinical outcomes in patients with head and neck and cervical cancer treated with radiotherapy. Although the biological explanation for this relationship between lactate and treatment response r...

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Bibliographic Details
Main Authors: Eric Leung, Rob A. Cairns, Naz Chaudary, Ravi N. Vellanki, Tuula Kalliomaki, Eduardo H. Moriyama, Hilda Mujcic, Brian C. Wilson, Bradly G. Wouters, Richard Hill, Michael Milosevic
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Cancer
Subjects:
Hypoxia
Hif-1α
Glycolysis
Lactate
Radiation response
Metabolism
Online Access:http://link.springer.com/article/10.1186/s12885-017-3402-6

Internet

http://link.springer.com/article/10.1186/s12885-017-3402-6

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